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World: Statement on the 9th IHR Emergency Committee meeting regarding the international spread of poliovirus

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Source: World Health Organization
Country: Afghanistan, Equatorial Guinea, Jordan, Lao People's Democratic Republic (the), Lebanon, Nigeria, Pakistan, Turkey, World

**WHO statement **

The 9th meeting of the Emergency Committee under the International Health Regulations (2005) (IHR) regarding the international spread of poliovirus was convened via teleconference by the Director­General on 12th May 2016. As with the seventh and eighth meetings, the Emergency Committee reviewed the data on wild poliovirus as well as circulating vaccine­derived polioviruses (cVDPV). The latter is important as cVDPVs reflect serious gaps in immunity to poliovirus due to weaknesses in routine immunization coverage in otherwise polio­free countries. In addition, any further spread of type 2 cVDPVs is a public health emergency following the globally synchronized withdrawal of type 2 OPV completed 1st May 2016.

The following IHR States Parties submitted an update on the implementation of the Temporary Recommendations since the Committee last met on 12th February 2016: Afghanistan, Guinea, Lao People’s Democratic Republic, Nigeria and Pakistan.

Wild polio

The Committee noted that since the declaration that the international spread of polio constituted a Public Health Emergency of International Concern (PHEIC) in May 2014, strong progress has been made by countries toward interruption of wild poliovirus transmission and implementation of Temporary Recommendations issued by the Director­ General. There has been a decline in the occurrence of international spread of wild poliovirus, with no international spread in 2015 or thus far in 2016 except between Afghanistan and Pakistan.

The Committee was encouraged by the intensified efforts and progress toward interruption of poliovirus transmission in Pakistan and Afghanistan despite challenging circumstances, and the renewed emphasis on cooperation along the long international border between the two countries. The committee particularly applauded the strong progress being made in Pakistan, with consistent evidence of reduced transmission in 2016, and welcomed Pakistan’s determination to complete eradication this year.

The Committee noted however that the international spread of wild poliovirus has continued, with two new reports of exportations from Pakistan into Afghanistan, one of which had occurred in October 2015 but only recognized recently following a new analysis of genetic data, and the second more recently in February 2016. These cases occurred in Nangarhar and Kunar Provinces, in the eastern region, adjoining the Pakistan border. While there has been no new exportation from Afghanistan to Pakistan, ongoing transmission particularly in inaccessible parts of the Eastern Region of Afghanistan close to the international border presents an ongoing risk. The new virus in Kunar was closely related to Pakistan viruses circulating at least since June 2014 in the Khyber-Peshawar block. The new Afghan virus in Nangarhar was closely related to Pakistan viruses also circulating during 2015 in the Khyber-Peshawar block.

The committee expressed its appreciation of the ongoing scientific cooperation between the Polio Regional Reference Laboratory in Islamabad and the Global Polio Specialized Laboratory in Atlanta to monitor the genetic characteristics and poliovirus sub-types in Pakistan and Afghanistan, and noted that the powerful tools employed to do this would be of great benefit in the polio endgame. This closer tracking of WPV1 means that chains of transmission across the border are more likely to be detected than in the past.

The committee reaffirmed that under the IHR, spread of poliovirus between two Member States constitutes international spread. The Committee acknowledged that cross border collaboration efforts have continued to be strengthened. Whilst border vaccination between these two countries is limited to children under ten years of age, efforts are being made to vaccinate departing travellers of all age groups from airports when leaving this epidemiological block formed by the 2 countries. The committee noted that all countries, and particularly those with embassies in Afghanistan and Pakistan, should facilitate implementation of Temporary Recommendations through adopting procedures that include proof of polio vaccination as part of visa application processes for travellers departing from Afghanistan or Pakistan, and urged the WHO secretariat to further assist in developing this process.

The committee was particularly concerned by the deteriorating security in parts of Afghanistan leading to more children becoming inaccessible, heightening anxiety about completion of eradication in 2016, thereby delaying the global polio endgame. The committee also noted that globally there are still significant vulnerable areas and populations that are inadequately immunized due to conflict, insecurity and poor coverage associated with weak immunization programmes. Such vulnerable areas include countries in the Middle East, the Horn of Africa, central Africa and parts of Europe.

The hard­ earned gains of the GPEI can be quickly lost if there is re­introduction of poliovirus in settings of disrupted health systems and complex humanitarian emergencies. The large population movements across the Middle East and from Afghanistan and Pakistan create a heightened risk of international spread of polio. There is a risk of missing polio vaccination among refugee and mobile populations, adding to missed and under vaccinated populations in Europe, the Middle East and Africa. An estimated 3 to 4 million people have been displaced to Jordan, Lebanon, and Turkey and are at the centre of a mass migration across Europe.

The committee acknowledged receipt of final reports as requested from Israel, South Sudan and Iraq, and agreed that these three countries are no longer subject to the Temporary Recommendations. However, noting some gaps in surveillance in South Sudan and Iraq, the committee urged the GPEI and partner organizations to continue to provide support to these countries, in addition to Ethiopia and Syria which sent their final reports in February.

Vaccine derived poliovirus

The current circulating vaccine­derived poliovirus (cVDPV) outbreaks across four WHO regions illustrate serious gaps in routine immunization programs, leading to significant pockets of vulnerability to polio outbreaks. In 2015, six outbreaks of circulating vaccine derived poliovirus occurred – three cVDPV type 1 outbreaks (Lao People’s Democratic Republic, Madagascar and Ukraine) and three cVDPV type 2 outbreaks (Guinea, Myanmar and Nigeria). In 2016, transmission is continuing in Lao People’s Democratic Republic, Nigeria and possibly Guinea.

In Guinea, the outbreak appears to be confined to one region, Kankan, but there appears to be a medium to high risk of continuation beyond OPV2 withdrawal. The possibility of missing transmission cannot be ruled out due to gaps in surveillance that were identified during the outbreak response assessment. Furthermore, surveillance indicators in neighbouring Liberia and Sierra Leone are below required standards and urgent efforts are needed to enhance surveillance in these countries.

The committee noted that in Lao People’s Democratic Republic there was ongoing circulation of vaccine derived polioviruses, particularly in hard to reach populations, underlining the importance of communication to counteract vaccine hesitancy. The lessons learnt from the ongoing efforts in the cVDPV outbreak should be used to revise the existing communication and social mobilization plan for routine immunization so as to address the vaccine hesitancy in these communities, including the use of local vernacular mobilization materials, intensified routine immunization campaigns in all identified high-risk and hard-to-reach areas to improve the vaccination coverage, revision of microplanning for routine vaccination to identify the high risk communities in every catchment area, and assessing the vaccination coverage in these communities during periodic coverage surveys.

The committee was very concerned that in Nigeria, a circulating vaccine-derived poliovirus type 2 (cVDPV2) has been detected in an environmental sample in March 2016 in Maiduguri, Borno State, north-east Nigeria. Genetic sequencing of the isolated strain indicates it is most closely linked genetically to a cVDPV2 strain from Borno in November 2013 and last detected in May 2014, indicating the strain has been circulating without detection for almost two years, but different to the strain identified in 2015 in the Federal Capital Territory and Kaduna. The committee noted that a very robust outbreak response is under way by the Government of Nigeria, but was concerned that the risk of international spread of this strain of cVDPV2 from Nigeria was high. Surveillance and immunization activities need to be strengthened in neighbouring countries in the Lake Chad region.


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